A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.
The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.
KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.
This is what the new class of weight loss drugs like Ozempic and Wegovy do. They also appear to help curb other addictions like alcohol. But good luck affording them right now.
I had actually looked into that and yeah, because it isn’t technically indicated for weight loss most insurance companies have dropped covering it barring severe medical need. Unfortunately, I’m like 80lbs overweight, and even having high blood pressure wasn’t enough to drop the $300/no it would cost out of pocket.
It makes sense, I mean why cover $300/mo while I lose weight when you can cover my eventual six figure bypass and hospital stay, or roll the dice and hope I just die?
I did hear that there is some version of it that has (or is soon getting) approval for weight loss so… maybe!