lol mine is also a cat! Its of my 14 year old Kaya when she was 4 or 5 months old.

Well, as a pharmacist whose been stable on 50mg of vyvanse for more than 3 years, your wife and Doc are both incorrect…

Both are stimulants, yes, but

Vyvanse is an amphetamine and works to produce more neurotransmitters you don’t already have.

Cocaine is a reuptake inhibitor… thus preventing the breakdown of neurotransmitters you do already have.

While fundamentally they may look like they’re doing the same thing, they are in fact 2 totally different mechanisms. Furthermore, in neurotransmitter depletion the effects of cocaine will severely diminish, where as amphetamines will thrive.

Just a heads up, but most states have laws that guard against rain water capture. For example Colorado only allows 2 barrels or 110 gallons per year!

https://extension.colostate.edu/topic-areas/natural-resources/rainwater-collection-colorado-6-707/

Avg US citizen uses 100 gallons/day

https://portal.ct.gov/-/media/Departments-and-Agencies/DPH/dph/drinking_water/pdf/27icwaterfactspdf.pdf

Def not a math major (BS/PharmD), but your explanation was like seeing through a visual illusion for the first time! lol

I was always taught PEMDAS growing up, and that the MD and the AS was read left to right in an equation like above. But stating the division as a fraction completely changes my mind now about how this calculation works. I think what would happen in a calculation I use every day if the former was used.

Example: Cockcroft-Gault Equation (estimation of renal function)

(140-age)(kg) / 72(SCr) vs (140-age) X kg ➗72 X SCr

In the first eq (correct one) an 80yo patient who weighs 65kg and has an SCr ~ 1.5 = 36.11

In the latter it = 81.25 (waaay too high for an 80yo lol)

edit: calculation variable

Maybe it’s early in the morning and I am not quite awake, but I have no idea what you are talking about. Nor do I understand how forgetting to do something makes you able to do something, and somehow that relates to a hot stove?

Can you explain what the “hot stove” example is? Maybe that is what I’m missing.

Are you using the EA version or the standard?

So, as a pharmacist, I can tell you that Tetracyclines (class of drug which includes Doxy, Minocycline, Tetracycline) have been used as prophylactic drugs for quite a long time, and not just for their anti-microbial activity.

Minocycline for example is used prophylactically for recurrent UTIs, suspected meningitis, and frequent SSSI by staph

Doxycycline has been used long term for Acne prevention, Malaria prophylaxis, and STI treatment and prophylaxis.

While I do worry about overuse of Antibiotics in general. It seems that tetracyclines as a class have been used quite frequently over the last 50+ years. I am sure that in small pockets of the LGBT+ populations (the scope of this indication, it seems) you may see some resistance that will need to be treated with other antibiotics, but I don’t think that we will see much cross-over into the general public. Furthermore, it looks like their is a new class making its way to hospitals soon that can get around the resistance seen, but we will need more studies to further nail that down.

So unless you live in an area with fiber, asymmetrical speeds are pretty typical… I’m not sure if it is because it’s all coax so there are infrastructure limitations? But it’s actually gotten faster because 6 months ago my upload was only 30 mbit/s.

Once fiber is in my area I’ll switch to that, but symmetrical will add more cost…but of course it will lol

Since the day before the Reddit strike… so mid June?

pay $180/month for 1gbit down/100mbit up and it is unlimited… It would be $130 for 1.75TB, but I wanted unlimited and that is an extra $50/month

No, not aspirin. We know aspirin very well in the medical community.

TBF there are drugs out there that we do not know the MOA of, like methocarbamol (from the national institute of health: “The exact mechanism of action of methocarbamol remains unknown; similarly unknown is the relationship between musculoskeletal pain and muscle spasm” lol)

So for long term safety, it is based on animal and human studies. These studies happen for multiple years prior to being put on the market (for the most part, though that is a story for a different day). Then after the drug is on the market, the drug company is required to do “Postmarket Clinical Studies” to show that their drug is still doing what it was initial shown to do; furthermore, to look for safety events of said drug.

A really famous case of a bungled postmark study was Vioxx. Vioxx is/was a Cox-2 specific pain medication. In the initial and postmarket studies they found that it had an increased risk of heart attack (in some cases up to 88% increased risk). The company Merck held the information from the public and FDA. They were forced to take the drug off the market in 2004. Technically in short bursts Vioxx was probably safe, but long term it was not.

Well how specific is enough to say we do or don’t know how a drug works?

In particular we do know that ASA and other NSAIDS work by inhibiting the activity of the enzyme called cyclooxygenase which leads to the formation of prostaglandins that cause inflammation, swelling, pain and fever. It blocks both COX 1 and 2, though only COX 2 is responsible inflammation. Furthermore, The antithrombotic action of aspirin is due to inhibition of platelet function by acetylation of the platelet cyclooxygenase at the functionally important amino acid serine529.

Now contrast ASA with Acetaminophen …

We know that Acetaminophen also inhibits COX, but only in the CNS and not peripherally. Also, it is only thought that it potentially blocks pain signals via the serotonergic pain pathway.

I would say we know a hell of a lot about aspirin … Acetaminophen not so much on the MOA side of things, however it has been studied so much that we know the safety/toxicity profile like the back of our hands. Either way probably not the best 2 examples to use for your argument.

Christian brings up some great points worthy of consideration; however, if your going to use traditional routing through their network (A/cname) your still doing the same thing. CF will still see your traffic.

The second thing I should say is, I only use zero trust for websites I share with family. So, I have a Searxng and wef/voyager dockers running through zero trust.

For admin, homeassistant/iot/ip cams, I use an always on IPSec vpn on my iPhone, iPad, and steam deck (take it to work and plug into 3rd monitor) … this is cool because I get 24/7 ad blocking no matter where I am because it routes all my traffic through my pihole at home. This is a great solution for a single person, but I do not want to manage vpn access for multiple ppl. So, I agree with christian in NOT putting admin stuff/sensitive info behind CF at all (zero trust OR tradition web routing) unless you fully trust them. Otherwise do a 24/7 vpn like I do.

I do this for some dockers in my unraid, except I use the zero trust tunnels. MUCH easier, can use SSL, and can set up a login page for users. Also, you don’t have to open any ports on your router!

Im not sure about synology, but I would assume you can find a “cloudflared” docker in the app store.

check out this youtube video for a good explanation: https://www.youtube.com/watch?v=ZvIdFs3M5ic

1. Parents are southern baptist and tithe 10% yearly

2. Constantly complain about socialism, and taxes

3. Go on mission trips to Haiti to help build homes

4. Constantly complain about refugees and immigration

5. Claims to have lgbt, black, etc minority friends

6. Sees nothing wrong with current Supreme Court trend taking rights away from said minority groups…

7/8. Think of any two things that are opposites between real life, what religion should be about, and politics… and it is someway twisted in a way you wouldn’t think would be possible.

TLDR: there is no way of dealing with this cognitive dissonance. It is maddening. I’ve gotten to the point of trolling my fam with republican Jesus lol. It’s the only thing that makes me at least laugh about the insanity.

+1 for SearXNG… I run my own instance in docker, and host it through a cloud flare tunnel. I set all my “web browser bars” on all my devices to auto use its address, so I don’t even have to think about it, and all my searches are auto routed through my instance. It’s Great!

That’s good to hear, it’s an awesome system if you already have a 3d printer

Small usb-c dongle

microsoft surface mouse

pro flip case

And a 3D printed adapter (3m taped to case) and kickstand from https://deckmate.me/ (was able to get stl files at no charge way back)

Then my standard charger for all my devices is the anker 715 + anker usbc power line III cable 6ft

Currently my UPS is reporting 207 watts, that’s with a unraid server (3600 + 32GB ram + 2060 super for plex, and 6 drives), a mini pc for pf sense, a rpi 4 running pihole and vpn server, a single poe ap, a modem, and security cameras… it can spike to 250w with multiple encodes going on from family … but overall not bad… I did have a dedicated 20A switch installed for just my network closet as well

Thankfully with the knowledge from my server, the switch will be more kind than if I’d never touched Linux before.

For real man, close to a decade ago I started off with a raspberry pi b+ and literally copying and pasting every code I found, and today I feel I can do almost anything I want in Linux. Moving from tinkering with Xbmc and retropies, to setting up openhan and pi-holes, then moving on to dockers, home assistant, and web-servers to building out a server/networking closet and running cat6 through the house lol

I love that the steam deck has a desktop mode as well. If steamos was out for desktop AND it supported nvidia (which it currently doesn’t), then that would be my new OS and I’d drop windows today.