It would be the same for any self replicating thing. Bacteria, viruses, fungi, and prions, but they replicate. I will grant you a single large parasite could do this, but at that point, we’re talking about tigers and such as a technicality as well.
None of the things you’ve listed here are single molecules except for the prion. A single cell, even for simple organisms, is made up of millions of proteins. Viruses come close, but are still made up of the nucleus and the capsid.
I like the constitution because I don’t want Matt Gaetz to be able to propose whatever nonsense he wants. It’s not a perfect document, but it enshrines certain fundamental protections that really shouldn’t be fucked with.